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Remark: Barbiturates might raise adverse effects, like respiratory despair, produced by poisonous doses of TCAs. With therapeutic doses of TCAs, barbiturates maximize metabolism and reduce blood concentrations of TCAs.Barbiturates may perhaps impair the psychological and/or Bodily talents essential for your general performance of potentially harmfu

Monitor Closely (one)phenobarbital will decrease the level or outcome of fentanyl transmucosal by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Coadministration of fentanyl with CYP3A4 inducers could lead on to your decrease in fentanyl plasma concentrations, deficiency of efficacy or, quite possibly, impr